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Nebivolol should not be used during pregnancy unless clearly necessary. If treatment with nebivolol is considered necessary, the uteroplacental blood flow and the foetal growth should be monitored. In case of harmful effects on pregnancy or the fetus alternative treatment should be considered. Symptoms of hypoglycaemia nebivolol 5 mg generic and bradycardia are generally to be expected within the first 3 days. No dose adjustment is required in mild to moderate renal insufficiency since uptitration to the maximum tolerated dose is individually adjusted. There is no experience in patients with severe renal insufficiency (serum creatinine ≥ 250µmol/L).